Cannabis research these days is focused on the endogenous cannabinoid systems (ECS), discovered in 1992. The ECS is a physiological system found internally (“endo”) in all mammals. It creates natural cannabinoids (the best known are anandamide and 2AG) that help the body maintain balance, a process called homeostasis. Cannabinoids found in the cannabis plant mimic those internal cannabinoids. When our homeostasis in “out of kilter” using cannabis can help regain the body’s internal balance.
There is a great deal to learn about the ECS and scientists around the world are captivated by this newly discovered physiological wonder. In 1993 there were just 10 studies of the ECS found in PubMed, the national database for scientific research. By 2015 that number had exploded to 6,521!
Insys Therapeutics, the Arizona-based pharmaceutical company that recently became the biggest financial supporter of the campaign against marijuana legalization in that state, makes an oral spray that delivers the opioid painkiller fentanyl and plans to […] Source: Medical Marijuana Seems To Reduce Deaths From Pharmaceuticals
As states grapple with the re-integration of medical cannabis into the physician’s compendium, there are hundreds of small dramas being played out all across the nation, indeed all around the globe. Many go unreported except for local coverage. The process isn’t as sexy as tie-dyed hippies with mammoth bongs and glazed expressions so it […]
A researcher in Israel is preparing to study the potential beneficial effects of cannabidiol (CBD) on children and adults with autism. Source: Israeli Doctor to Study Cannabis’s Effect on Autism – Medical Marijuana Inc. (OTC: MJNA) Editor’s note: Autism is complex, to say the least, and researching the effects of CBD on autistic children will […]
Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable attention as a potential target for the treatment of glaucoma, largely […]
Ethan Russo forwards a slightly revised “Beyond Cannabis: Plants and the endocannabinoid system,” published in Trends in Pharmacological Sciences, with “the hope that this will raise consciousness on the endocannabinoid system and its importance and ubiquity.”Russo was an early proponent of the idea that an overall endocannabinoid deficiency —insufficient “endocannabinoid tone”— may be responsible for […]
The CB2 receptor is one of the components of the endogenous cannabinoid system, a complex network of signaling molecules and receptors involved in the homeostatic control of several physiological functions. Accumulated evidence suggests a role for CB2 receptors in Alzheimer’s disease (AD) and indicates their potential as a therapeutic target against this neurodegenerative disease. To […]